Two sample MR report
LTC4S_Endothelial Cell (Endo) against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | 0.2869946 | 0.6832360 | 0.7468341 |
| Weighted median | 3 | -0.0408751 | 0.0165574 | 0.0135610 |
| Inverse variance weighted | 3 | -0.0411218 | 0.0136387 | 0.0025691 |
| Simple mode | 3 | -0.0422628 | 0.0187893 | 0.1534255 |
| Weighted mode | 3 | -0.0401547 | 0.0194562 | 0.1750855 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0060737 | 1 | 0.9378807 |
| Inverse variance weighted | 0.2367948 | 2 | 0.8883430 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.1756638 | 0.3657115 | 0.714927 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 4e-05 | 0 | TRUE | 0.5501537 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
